Yk11 Review: Myostatin Inhibitor Sarm

YK11 was discovered in 2011 by Yuichiro Kanno of Toho University. It is a steroidal selective androgen receptor modulator (sarm). It is a gene-selective partial agonist of the androgen receptor

YK11 is actually a myostatin inhibitor. Myostatin inhibits muscle growth. So by inhibiting the inhibitor, YK11 should elicit more pronounced muscle growth and has also been shown to be more anabolic than dihydrotestosterone (DHT).

Here is a published study on YK11 that is worth a read.

Is YK-11 a Steroid or a SARM?

YK-11 was discovered When Yuichiro Kanno  discovered YK-11, he dubbed it as a potential anabolic SARM. However, that label is a little misleading because it certainly has more in common with a steroid than a SARM.

One could theorize that the creators of this compound advocated it be referenced as a myostatin inhibiting SARM. Due to the social stigma attached to AAS, continued research funding for YK11 would be unlikely if labeled a steroid.

YK11 has a very similar chemical structure to Testosterone and DHT.  This would explain why YK-11 has been shown to be more anabolic than dihydrotestosterone (DHT).

Is Yk11 liver toxic?

Many believe this compound to be very liver toxic. This is because YK11 features a methyl ester which allows for oral bioavailability inhibiting it’s hepatic metabolism.  However, most fitness enthusiasts don’t understand chemistry and fail to realize that there is a difference between 17-alpha alkylation and a simple methyl group.

A methyl at the 17th position AKA 17-alpha alkylation causes liver toxicity but having another methyl groups somewhere else wouldn’t necessarily make it more toxic. This explains why various researchers reported doing blood tests during use of YK11 with results indicating little to no liver damage.

My personal experience using Yk11

My encounter with YK11 began while I was running a cycle of RAD-140. RAD-140 is hands down my favorite sarm and I’ve used it on three different occasions. But I was looking for something that I could stack it with to see even more pronounced results.

I had seen some of the hype around Yk11 for about a year now. And my understanding of the compound was that even though it was still technically a sarm, it had a different mechanism of action than traditional sarms like Ostarine, LGD-4033, and RAD-140. And based off my awesome experience with stacking two compounds that work differently (MK-677 and Ostarine), I thought I would give this a go.

Dosage and cycle length

This compound does not have a 24 hour half-life like most sarms. And it is my understanding that it will last in your system around 8 to 10 hours. Therefore, my testing was broken up into two doses a day of 7.5mg. One dose in the morning and one at night for a total of 15mg per day.

I personally think that this compound needs to be stacked with a base compound such as LGD4033, Ostarine, or RAD-140. Cycles need to be kept at a four week long duration due to the tendon issue that I mentioned. Therefore, I would implement YK11 during the last four weeks of this cycle as a finishing touch.

YK11 Side effects

I’m not gonna lie. I didn’t really know what to expect with YK11 because I’ve read all kinds of horrific broscience bullshit about this compound from various sources. Some have said that it’s the most suppressive thing ever made and will shut you down where you can’t even get a hard on. I’ve also read that it is highly toxic and will wreck your liver based on its molecular structure.

I know this may have been because of the RAD-140 but I didn’t have any issue with getting shutdown or maintaining a healthy sex drive. I don’t know if this would have been different if I had just tested YK11 by itself though because my sex drive goes through the roof every time I use RAD-140. So I honestly couldn’t tell you how this would go as a stand alone.

However, I always  suggest running some sort of PCT after discontinued use of any anabolic compound.

I didn’t really see any negative issues with liver profiles like a bunch of the dipshits on forums seem so certain of. Even though they’ve never used the stuff themselves.

Yk11 joint pain

The ONLY negative thing I noticed was some pretty unusual aching in my hips and shoulders after 5-weeks of testing. It wasn’t unbearable but it would come and go if I was stuck setting in a long car ride or didn’t stretch long enough before a shoulder workout.

I think this has to do with the relationship between tendon strength and myostatin inhibitors that I couldn’t even begin to explain.

All I know is that the joint pain went away after I stopped taking it. Therefore I would suggest that you guys keep testing around 4 weeks to avoid this side effect. This was plenty of time to see the awesome benefits of this compound. So let’s talk about what positives I experienced.

Benefits

I got amazing strength gains after about a week of taking this stuff! The best way I could describe it was that I felt I had a certain command of heavier weights. I was banging out more reps on heavy weights and felt confident every time I decided to add weight to my maximums.

Stuff that usually does this tends to come with a lot of water retention but I didn’t have ANY of that. I’m talking zero shitweight from water bloat.

I really think that most of the gains I got probably came from my beloved RAD-140 but there is no doubt that I saw some nice changes in body composition due to being able to punch more weight.

The most noticeable thing though was how easily I could get a pump. I’m not exaggerating here when I say that I could just do some hard flexing to get a muscle group engorged with blood. So I’m sure that blood and nutrients getting to the various muscle groups easier contributed to my awesome experience here.

Suggested Source For YK-11

I’ve used this compound with two different sources with great success.

If your looking for liquid sarms, then CHEMYO is the company you want to take a look at. They’ve been around forever and have a great reputation for having great consistency with product quality and service. Additionally, They also post all their 3rd party testing results on each product page so you know that what your getting is actually real.

You can get 10% off any of their items by using the discount code: LEAVINGWEAKNESS10

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1 Comment

  1. Jeff

    I tried yk11 from mma overload and I got lethargic I fought through it , didn’t get much strength BENNIFIT or muscle size. .kinda disappointed. So not going to buy from there again..

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