There are dozens of PPAR delta agonists in the pipeline which are in phase 2 and 3 clinical trials such as Elafibranor (GFT505) and Seladelpar (MBX-8025). However, There is a very interesting PPARβ/δ agonist called GW-0742, which is being dubbed as a ‘Super Cardarine’.
GW-0742 vs GW-501516
GW-0742 is a PPARβ/δ agonist that structurally looks like Cardarine(GW501516) but with one hydrogen atom replaced with a fluorine atom.
From what I can tell is that it has all the positive traits of Cardarine with added benefits.
Like Cardarine, GW0742 has shown very impressive research results in body fat reduction and performance enhancement.
GW-0742 differs from GW-501516 due to enhanced synthesis and biological activity with user reports indicating it to be much more potent with more drastic results.
Currently there are no human trials to work with, and no animal trials looking at body composition / endurance (yet)
GW0742 Benefits
Here are the notable things I came across:
- Increases Insulin Sensitivity in rats
- In diabetic rats fed a high fructose diet, the group given GW0742 had lower blood sugar than control, and insulin sensitivity was increased
- Improves Expression of Type 2 Collagen and also indirectly reduced cartilage wear and tear
- Promotes reverse cholesterol transport. (This means is that it’s moving cholesterol back to the liver which should lower total cholesterol.)
- Reduces Inflammation in Gut
- Limits Right Heart Hypertrophy and shown to be cardiac protective
- Enhances Lipid Metabolism
GW0742 Side Effects
I previously dispelled the cancer myths surrounding Cardarine HERE. However, those with concerns about Cardarine causing cancer will be pleased to know that no studies have shown GW0742 to cause cancer.
The only side effect that I notice came from one rat study mention seeing cardiomegaly through activation of calcineurin. But I think it was the much higher dosage this was observed at, rather than the more conservative dosing utilized in other studies.
Just keep in mind that too much of anything can find a way of causing problems, even water.
GW0742 Dosages
I’ve discussed this compound with several researches who have taken it and discussing it with associates of mine with medical degrees. My conclusion is that a more conservative daily dosage ranging between 10mgs and no more than 15mg could be considered safe if utilized in shorter durations of 8 weeks or less. This was considered when comparing the more conservative rat dosages to the size of a human test subject.
This is certainly an interesting compound and thought you guys would enjoy the info!
Where to get GW0742
If you are interested in obtaining GW0742 for your own research, our good friends at the following companies have this compound:
CHEMYO and use the coupon code LEAVINGWEAKNESS10 to get 10% off any of their research materials.
Amino Asylum and use the coupon code LW20 to get 20% off any of their research materials.
What does 25mg look like in a ml dropper? To the 0.1ml mark?
The front of the bottle should have something that is indicative of a reference of mg per ml…
I’ll use an example of a product containing 25MG PER ML
So if you wanted to take 25mg you would take a full dropper (1.00 mark on the graduated dropper)
If you wanted to take 12.5mg you would take half a dropper (.50 mark on the graduated dropper)
If you wanted to take 5mg you would take 1/5 a dropper (.20 mark on the graduated dropper)
If you wanted to take 2.25mg you would take 1/10 a dropper (.10 mark on the graduated dropper)